Cov txheej txheem:

Acetylator qeeb yog dab tsi?
Acetylator qeeb yog dab tsi?
Anonim

Slow acetylators yog cov neeg uas lub siab tsis tuaj yeem tshem tawm cov tshuaj reactive metabolites Piv txwv li, cov neeg mob uas muaj sulfonamide-induced toxic epidermal necrolysis toxic epidermal necrolysis Toxic epidermal necrolysis (TEN) yog qhov muaj peev xwm. kev phom sij txog kev tuag taustus yam ntxwv los ntawm qhov dav erythema, necrosis, thiab bullous detachment ntawm epidermis thiab mucous daim nyias nyias, ua rau exfoliation thiab muaj peev xwm sepsis thiab/los yog tuag. https://emedicine.medscape.com › article › 229698-overview

Toxic Epidermal Necrolysis (TEN) - Medscape Reference

tau pom tias muaj qeeb acetylator genotype uas ua rau muaj kev tsim cov sulfonamide hydroxylamine ntau ntxiv ntawm txoj kev P-450.

Acetylators qeeb thiab ceev yog dab tsi?

Cov acetylator phenotype qeeb qeeb feem ntau ntsib kev toxicity los ntawm cov tshuaj xws li isoniazid, sulfonamides, procainamide, thiab hydralazine, whereas acetylator phenotype ceev yuav tsis teb rau isoniazid thiab hydralazine hauv kev tswj. ntawm tuberculosis thiab kub siab, feem.

Dab tsi yog qeeb thiab ceev acetylators piav qhia txog kev cuam tshuam rau acetylation ntawm isoniazid?

Metabolism ntawm isoniazid tshwm sim los ntawm acetylation. Hauv cov neeg mob uas muaj caj ces "ceev acetylators," isoniazid yuav tsis ncav cuag qib kho thiab yuav muaj cov plasma luv t ½pivnrog "slow acetylators. " Cov acetylators qeeb yuav muaj kev pheej hmoo ntau dua rau cov tshuaj toxicity vim yog cov tshuaj ntev t½

Dab tsi yog tshuaj acetylation?

Acetylation yog cov tshuaj tiv thaiv tshuaj uas hu ua ethanoylation hauv IUPAC nomenclature. Nws piav qhia txog cov tshuaj tiv thaiv uas qhia txog pawg acetyl ua haujlwm rau hauv cov tshuaj lom neeg. Cov tshuaj tiv thaiv tawm tsam yog hu ua deacetylation - nws yog kev tshem tawm ntawm pawg acetyl.

Cov tshuaj twg yog metabolized los ntawm acetylation?

Tshuaj uas paub tias metabolized los ntawm txoj kev no suav nrog procainamide, hydralazine, isoniazid, sulfapyridine, sulfadimidine, dapsone, ib qho amine metabolite ntawm nitrazepam, thiab qee cov carcinogenic aromatic amines. Nongenetic yam tseem tuaj yeem cuam tshuam tus nqi ntawm acetylation.

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