Cov txheej txheem:
- Acetylators qeeb thiab ceev yog dab tsi?
- Dab tsi yog qeeb thiab ceev acetylators piav qhia txog kev cuam tshuam rau acetylation ntawm isoniazid?
- Dab tsi yog tshuaj acetylation?
- Cov tshuaj twg yog metabolized los ntawm acetylation?
- Isoniazid { INH }: qeeb thiab ceev acetylators
2024 Tus sau: Simon Evans | [email protected]. Kawg hloov kho: 2024-01-13 03:51
Slow acetylators yog cov neeg uas lub siab tsis tuaj yeem tshem tawm cov tshuaj reactive metabolites Piv txwv li, cov neeg mob uas muaj sulfonamide-induced toxic epidermal necrolysis toxic epidermal necrolysis Toxic epidermal necrolysis (TEN) yog qhov muaj peev xwm. kev phom sij txog kev tuag taustus yam ntxwv los ntawm qhov dav erythema, necrosis, thiab bullous detachment ntawm epidermis thiab mucous daim nyias nyias, ua rau exfoliation thiab muaj peev xwm sepsis thiab/los yog tuag. https://emedicine.medscape.com › article › 229698-overview
Toxic Epidermal Necrolysis (TEN) - Medscape Reference
tau pom tias muaj qeeb acetylator genotype uas ua rau muaj kev tsim cov sulfonamide hydroxylamine ntau ntxiv ntawm txoj kev P-450.
Acetylators qeeb thiab ceev yog dab tsi?
Cov acetylator phenotype qeeb qeeb feem ntau ntsib kev toxicity los ntawm cov tshuaj xws li isoniazid, sulfonamides, procainamide, thiab hydralazine, whereas acetylator phenotype ceev yuav tsis teb rau isoniazid thiab hydralazine hauv kev tswj. ntawm tuberculosis thiab kub siab, feem.
Dab tsi yog qeeb thiab ceev acetylators piav qhia txog kev cuam tshuam rau acetylation ntawm isoniazid?
Metabolism ntawm isoniazid tshwm sim los ntawm acetylation. Hauv cov neeg mob uas muaj caj ces "ceev acetylators," isoniazid yuav tsis ncav cuag qib kho thiab yuav muaj cov plasma luv t ½pivnrog "slow acetylators. " Cov acetylators qeeb yuav muaj kev pheej hmoo ntau dua rau cov tshuaj toxicity vim yog cov tshuaj ntev t½
Dab tsi yog tshuaj acetylation?
Acetylation yog cov tshuaj tiv thaiv tshuaj uas hu ua ethanoylation hauv IUPAC nomenclature. Nws piav qhia txog cov tshuaj tiv thaiv uas qhia txog pawg acetyl ua haujlwm rau hauv cov tshuaj lom neeg. Cov tshuaj tiv thaiv tawm tsam yog hu ua deacetylation - nws yog kev tshem tawm ntawm pawg acetyl.
Cov tshuaj twg yog metabolized los ntawm acetylation?
Tshuaj uas paub tias metabolized los ntawm txoj kev no suav nrog procainamide, hydralazine, isoniazid, sulfapyridine, sulfadimidine, dapsone, ib qho amine metabolite ntawm nitrazepam, thiab qee cov carcinogenic aromatic amines. Nongenetic yam tseem tuaj yeem cuam tshuam tus nqi ntawm acetylation.
Pom zoo:
Puas yog pecs nrawm lossis qeeb qeeb?
Pectoralis loj yog cov leeg ua haujlwm thiab ob lub taub hau yog feem ntau nrawm nrawmhauv yuav luag txhua tus, nrog 60% hom II fibers yog qhov nruab nrab . Puas yog cov leeg hauv siab twitch lossis qeeb qeeb? Lub hauv siab yog nrawm nrawm, tab sis cov ntxiab yog cov leeg pob txha thiab ua rau qeeb qeeb, yog li koj yuav tsum ua ntau qhov ntim rau koj lub ntxiab dua li koj lub hauv siab.
Puas koj cov metabolism qeeb qeeb?
Kev tshawb fawb qhia tau tias koj cov metabolism yuav qeeb zuj zus nrog lub hnub nyoog Ua kom tsis muaj zog, poob cov leeg nqaij thiab kev laus ntawm koj cov khoom sab hauv txhua tus ua rau cov metabolism qeeb. Hmoov zoo, muaj ntau txoj hauv kev los tiv thaiv kev laus los ntawm kev ua kom koj cov metabolism hauv qeeb .
Puas yog qeeb qeeb pokemon zoo?
Slowking boasts kev tiv thaiv zoo heev, muaj peev xwm zoo hauv Regenerator, thiab tshwj xeeb tshwj xeeb nrog rau cov khoom siv lub cev zoo, ua rau nws yog ib qho ntawm NU qhov kev tiv thaiv zoo tshaj plaws pivots, noj rau Passimian, Delphox, thiab Mega Glalie ntseeg tau .
Leej twg yog acetylator qeeb?
Slow acetylators yog cov neeg uas lub siab tsis tuaj yeem tshem tawm cov tshuaj reactive metabolites Piv txwv li, cov neeg mob uas muaj sulfonamide-induced toxic epidermal necrolysis toxic epidermal necrolysis Toxic epidermal necrolysis (TEN) yog qhov muaj peev xwm.
Puas yog rov qab nrawm lossis qeeb qeeb?
Feem ntau ntawm cov leeg hauv koj lub cev muaj ntau dua ib hom nqaij fiber ntau. Tab sis qee cov leeg muaj ntau dua qeeb-twitch fibersvim lawv yuav tsum ua tib txoj haujlwm ntev. Piv txwv li, cov leeg hauv qab ntawm koj ob txhais ceg thiab cov leeg hauv koj nraub qaum feem ntau yog ua los ntawm qeeb-twitch fibers .